UPDATE, Feb 7, 2016: The Zodiac Pattern Drawer site at sbabaker.com went down, so I attempted to mirror the tool here: http://zodiackillerciphers.com/zodiac-pattern-drawer/
Computer science professor Ryan Garlick at the University of North Texas has been enlisting his students to try out different ways to solve Zodiac’s 340-character cryptogram. Many people believe that the 340 needs to be re-arranged before it can be cracked. So, this year, Dr. Garlick’s students developed the “Zodiac Pattern Drawer”, a web-based tool that lets you re-arrange the 340 and download the result.
Basically, you start with the original cryptogram, and click around in it to draw a different path through its symbols. Your rearranged symbols appear on the right, and when you are done, you can download a text file that contains a numerical representation of the new cryptogram. You can then take that file and feed it to an automatic solver such as zkdecrypto or AZdecrypt.
Hopefully someone can find a rearrangement that leads to a solution!